Getting a Grip on Microtubules

Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules.

The kinetochore links chromosomes to dynamic spindle microtubules and drives both chromosome congression and segregation. To do so, the kinetochore must hold on to depolymerizing and polymerizing microtubules. At metaphase, one sister kinetochore couples to depolymerizing microtubules, pulling its sister along polymerizing microtubules [1, 2]. Distinct kinetochore-microtubule interfaces mediate...

Getting a grip on guidelines: how to make them more relevant for practice

Influence of taxol and CNTs on the stability analysis of protein microtubules

Microtubules are used as targets for anticancer drugs due to their crucial role in the process of mitosis. Recent studies show that carbon nanotubes (CNTs) can be classified as microtubule-stabilizing agents as they interact with protein microtubules (MTs), leading to interference in the mitosis process. CNTs hold a substantial promising application in cancer therapy in conjunction with other c...

Microtubule Dynamics: Kinetochores get a grip

Analysis of the interactions between purified motor proteins or isolated chromosomes and shrinking microtubules has shed light on the mechanism of chromosome segregation at mitosis.

Getting a grip on costs and usage of spinal implant technologies.